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Paget Disease

[Summary]Paget Disease of the Breast A fact sheet about Paget disease of the breast, a rare type of cancer that is sometimes called Paget disease of the nipple or mammary Paget disease. Fast Facts About Paget's Disease of Bone November 2014 Paget's disease ca

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Paget Disease of the Breast

A fact sheet about Paget disease of the breast, a rare type of cancer that is sometimes called Paget disease of the nipple or mammary Paget disease.

Fast Facts About Paget's Disease of Bone

November 2014

Paget’s disease causes bones to grow too large and weak. You can have Paget’s disease in any bones in your body, but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones, but it does not affect the entire skeleton. Bones with Paget’s disease may break more easily, and the disease can lead to other health problems.

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Overview - Mayo Clinic

Paget Disease

Paget's Disease - NORD (National Organization for Rare Disorders)

Paget's Disease of the Breast

Paget Disease

Paget's disease of the breast, also known as Paget disease of the nipple or mammary Paget disease, is a rare form of breast cancer that represents less than 5 percent of breast cancer cases.

Paget's Disease of the Breast

JOURNAL ARTICLES
Wong SM, Freedman RA, Sagara Y, et al. The effect of Paget disease on axillary lymph node metastases and survival in invasive ductal carcinoma. Cancer. 2015 Dec 15;121(24):4333-40. http://www.ncbi.nlm.nih.gov/pubmed/26376021

Fouad D. Paget’s disease of the breast in a male with lymphomatoid papulosis: a case report. J Med Case Reports. 2011;5:43. http://www.ncbi.nlm.nih.gov/pubmed/21276228

Paget disease of the breast

INTRODUCTION

In 1874, Sir James Paget described 15 women with chronic nipple ulceration who all went on to develop cancer of the involved breast within two years [1]. The ulceration was described as an eczema-like eruption on the nipple and areola with a copious clear yellowish exudate. Ultimately, this would become known as Paget disease of the breast (PDB) or mammary Paget disease. While Paget believed that the nipple changes were themselves benign, it was subsequently discovered that the characteristic cells within the epidermis of the nipple (Paget cells) were in fact malignant [2].

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