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Explain Drug Tolerance

[Summary]How Drug Tolerance Changes the Brain How Drug Tolerance Changes the Brain Dopamine is a neurotransmitter. Neurotransmitters are released from neurons and travel in the microscopic spaces (called "synapses") to inter- Addiction, Dependence, and T

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How Drug Tolerance Changes the Brain

Explain Drug Tolerance

How Drug Tolerance Changes the Brain Dopamine is a neurotransmitter. Neurotransmitters are released from neurons and travel in the microscopic spaces (called “synapses”) to inter…

Addiction, Dependence, and Tolerance

Confusion with Addiction Terminology

There can be a great deal of confusion surrounding the words addiction, physical dependence, and tolerance. People will use these words as if they are referring to the exact thing, but there is a significant difference between them. Misunderstandings about these terms can not only be confusing for the general public but also many in the medical profession. One of the main culprits blamed for this confusion is the fact that the Diagnostic and Statistical Manual of Mental Disorders has chosen to use the word dependency instead of the word addiction and people assume this to mean physical dependency.

Addiction, Dependence & Tolerance | Drug Abuse & Addiction

Explain Drug Tolerance
Drug and alcohol abuse is a major public health concern. In 2014, nearly 88% of Americans said they had consumed alcohol at some point, and nearly 680,000 adolescents suffered from an addiction to alcohol.1 Illegal drug use has also risen in the last decade or so, with an estimated 9.4% of Americans aged 12 and older having reported illicit drug use.2 In 2013, there were nearly 3 million new illegal substance users and about 54% of them were adolescents.2

Marijuana Research: Tolerance to Cannabinoids

Herkenham's research continued, and subsequently discovered the mechanism of tolerance to marijuana.

Tolerance describes an adaptation by the brain to the continued presence of a drug in which higher doses of the drug are required to obtain the effect of the initial dose.

The classic model holds that tolerance contributes to the development of dependence, and that withdrawal symptoms reflect the brain's inability to function without the accustomed drug. In this model the withdrawal symptoms are supposed to be the opposite of the drug's effects. (27)

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